The interplay of vaccination and vector control on small dengue networks
نویسندگان
چکیده
Dengue fever is a major public health issue affecting billions of people in over 100 countries across the globe. This challenge is growing as the invasive mosquito vectors, Aedes aegypti and Aedes albopictus, expand their distributions and increase their population sizes. Hence there is an increasing need to devise effective control methods that can contain dengue outbreaks. Here we construct an epidemiological model for virus transmission between vectors and hosts on a network of host populations distributed among city and town patches, and investigate disease control through vaccination and vector control using variants of the sterile insect technique (SIT). Analysis of the basic reproductive number and simulations indicate that host movement across this small network influences the severity of epidemics. Both vaccination and vector control strategies are investigated as methods of disease containment and our results indicate that these controls can be made more effective with mixed strategy solutions. We predict that reduced lethality through poor SIT methods or imperfectly efficacious vaccines will impact efforts to control disease spread. In particular, weakly efficacious vaccination strategies against multiple virus serotype diversity may be counter productive to disease control efforts. Even so, failings of one method may be mitigated by supplementing it with an alternative control strategy. Generally, our network approach encourages decision making to consider connected populations, to emphasise that successful control methods must effectively suppress dengue epidemics at this landscape scale.
منابع مشابه
Prevention and Control Policies of Dengue Vectors (Aedes aegypti and albopictus) in Iran
Background and Objective: Dengue fever has become a major public health problem in many world regions due to increased trade, travel, and problems controlling Aedes vectors. This policy brief aims to review, analyze, and present evidence-based policies for dengue prevention and control. Methods: The present research is a compilation of a policy brief in Iran, carried out in 3 stages according ...
متن کاملControl and Management of Vector-Borne Diseases in Disaster Conditions
Disasters are a set of unexpected situations that occur as a result of natural misadventure or human manipulations. Depending on the type, time, and location of the events, the insect population causing vector-borne diseases is affected, which may eventually lead to widespread epidemics. Parasitic diseases such as malaria, leishmaniosis, arboviral diseases such as dengue fever, West Nile enceph...
متن کاملCharacterization of dengue virus in Aedes aegypti and Aedes albopictus spp. of mosquitoes: A study in Khyber Pakhtunkhwa, Pakistan
Dengue is a vector-borne disease caused by dengue virus. According to the recent report of CDC that one-third population of the world are at high risk with Dengue fever. The prevalence of the dengue hemorrhagic fever was found more in tropical and sub-tropical regions of the world. Aedes mosquitoes was reported as the main cause of transmission of dengue virus. So the current study was planned ...
متن کاملDesigning and Determining the Validity and Reliability of a Questionnaire to Assess Knowledge, Attitude, and Practice of Healthcare Workers about Dengue in Mazandaran Province, North of Iran
Background and purpose: The knowledge, attitude, and practice (KAP) of healthcare workers are important to reduce the transmission and burden of dengue. There is no standard tool to assess KAP of healthcare workers about dengue in Mazandaran Province, Iran, so this study was conducted to design and assess the validity and reliability of a questionnaire in Persian assessing KAP of healthcare wor...
متن کاملPhylogenetic Analysis of Aedes aegypti Based on Mitochondrial ND4 Gene Sequences in Almadinah, Saudi Arabia
Background: Aedes aegypti is the main vector of the yellow fever and dengue virus. This mosquito has become the major indirect cause of morbidity and mortality of the human worldwide. Dengue virus activity has been reported recently in the western areas of Saudi Arabia. There is no vaccine for dengue virus until now, and the control of the disease depends on the control of the vector. Objectiv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 407 شماره
صفحات -
تاریخ انتشار 2016